Golden Anniversary of the Nicotinic Receptor

The Giant Component: The Golden Anniversary

Oftentimes the beginnings of a mathematical area are obscure or disputed. The subject of Random Graphs had, however, a clear beginning and it occurred fifty years ago. Alfréd Rényi (1921-1970) was head of the Hungarian Mathematical Institute which today bears his name. Rényi had a great love of literature and philosophy, a true Renaissance man. His life, in the words of Paul Turán, was one of i...

Golden Anniversary: The Administrative Procedure Act of 1946, A

The resurrection of spironolactone on its golden anniversary.

The edematous states, specifically those in CHF and cirrhosis of the liver, are associated with excessive aldosterone secretion and represent states of secondary hyperaldosteremia. Aldosterone promotes sodium retention by the renal tubules. Spironolactone, first introduced 50 years ago (1953), blocks the action of aldosterone on renal transport of electrolytes, thus acting as an effective diure...

Discrete Optimization Assignment problems: A golden anniversary survey

Having reached the 50th (golden) anniversary of the publication of Kuhn s seminal article on the solution of the classic assignment problem, it seems useful to take a look at the variety of models to which it has given birth. This paper is a limited survey of what appear to be the most useful of the variations of the assignment problem that have appeared in the literature over the past 50 years...

A golden anniversary: cattle twins and immune tolerance.

0 CCASIONALLY a chance observation jump-starts a whole field of science. The discovery of immune tolerance and the recognition of self and nonself is such an event. It started with a 1944 letter from a cattle breeder in Maryland to the University of Wisconsin immunogenetics laboratory, reporting a curious pair of twin calves, unusual in having different fathers. RAY OWEN, a postdoctoral fellow ...